The NASA installation that has been the launch site for every United States human space flight since 1968. Although such flights are currently on hiatus, KSC continues to manage and operate unmanned rocket launch facilities for America's civilian space program from three pads at the adjoining Cape Canaveral Air Force Station. Its iconic Vehicle Assembly Building (VAB) is the fourth-largest structure in the world by volume and was the largest when completed in 1965.

Located on Merritt Island, Florida, the centre is north-northwest of Cape Canaveral on the Atlantic Ocean, midway between Miami and Jacksonville on Florida's Space Coast. It is 34 miles (55 km) long and roughly 6 miles (10 km) wide, covering 219 square miles (570 km²). A total of 13,100 people worked at the centre as of 2011. Approximately 2,100 are employees of the federal government; the rest are contractors.

Since December 1968, all launch operations have been conducted from Pads A and B at Launch Complex 39 (LC-39). Both pads are on the ocean, 3 miles (5 km) east of the VAB. From 1969–1972, LC-39 was the departure point for all six Apollo manned Moon landing missions using the Saturn V, the largest and most powerful operational launch vehicle in history, and was used from 1981–2011 for all Space Shuttle launches. The Shuttle Landing Facility, located just to the north, was used for most Shuttle landings and is among the longest runways in the world.

The KSC Industrial Area, where many of the centre's support facilities are located, is 5 miles (8 km) south of LC-39. It includes the Headquarters Building, the Operations and Checkout Building and the Central Instrumentation Facility. KSC was also home to the Merritt Island Spaceflight Tracking and Data Network station (MILA), a key radio communications and spacecraft tracking complex. The centre operates its own short-line railroad.

KSC is a major central Florida tourist destination and is approximately one hour's drive from the Orlando area. The Visitor Complex offers public tours of the center and Cape Canaveral Air Force Station. Because much of the installation is a restricted area and only nine percent of the land is developed, the site also serves as an important wildlife sanctuary Mosquito Lagoon, Indian River, Merritt Island National Wildlife Refuge and Canaveral National Seashore are other features of the area. Centre workers can encounter Bald Eagles, American alligators, wild boars, Eastern Diamondback rattlesnakes, Florida panthers and Florida manatees. KSC is one of ten major NASA field centres, and has several facilities listed on the National Register of Historic Places.